The Ihilov clinic employs a team of highly qualified specialists, many of whom have trained and interned at the best medical centers in the world. Significant experience in precise diagnostics and advanced approaches ensure successful treatment of precursor B-cell lymphoma in Israel. Patients receive an integrated assessment and treatment plan from a team of specialists, including hematologists, oncologists, histopathologists, radiologists, transplantologists, and doctors from other related fields. This ensures a comprehensive approach to treatment and disease management.
Ihilov is equipped with advanced diagnostic and therapeutic equipment, allowing the practice of the latest techniques. The doctors have targeted drugs, innovative chemotherapy, immunotherapy, and advanced radiation therapy methods using the latest generation linear accelerators.
Stays at Ihilov are organized to address all issues of treatment, communication, transportation, and accommodation for patients and their families, allowing them to fully focus on recovery.
About the Disease
Precursor B-cell lymphoma (precursor B cell lymphoblastic lymphoma) is one of the subtypes of B-cell acute lymphoblastic leukemia (B cell ALL/LBL). It is a rare, aggressive type of non-Hodgkin lymphoma. The disease arises from cells that are precursors to normal B-cells, which are in early stages of development, with the infiltration of blasts into extramedullary tissues.
According to the recommended WHO updates on the classification of malignant lymphomas, pathologies are diagnosed based on the immunophenotypic characteristics of the cells. Lymphoblastic neoplasms are divided into:
B-cell lymphoblastic leukemia/lymphomas (B-cell ALL/LBL)
T-cell lymphoblastic leukemia/lymphomas (T-cell ALL/LBL)
In the modern classification, precursor B-cell lymphoma is classified as a subtype of B cell ALL/LBL. A feature of the pathology is overlapping clinical manifestations characteristic of both leukemia and lymphoma.
The exact causes of the disease are not fully understood. It is known that the oncological process begins with one or a series of genetic mutations in precursor B-cells, leading to their uncontrolled division and growth. Additionally, researchers suggest the influence of other risk factors, including radiation exposure, chemical carcinogens, and hereditary predisposition.
The most common signs of precursor B-cell lymphoma include:
- rapidly enlarging painless lymph nodes
- fever, night sweats, unexplained weight loss (B-symptoms)
- fatigue and weakness
- frequent infections due to suppressed immune response
- enlargement of the liver or spleen (hepatosplenomegaly)
- bone or joint pain.
Treatment Methods for the Disease
Treatment of precursor B-cell lymphoma at the Ihilov clinic includes a combination of the most effective and promising methods, each selected based on the stage of the disease, the overall condition of the patient, and the goals of therapy.
Intensive Chemotherapy
The main treatment method is based on the use of cytotoxic drugs to destroy malignant cells. Chemotherapy typically consists of several cycles and may combine a set of drugs to which rapidly dividing lymphoma cells are most sensitive. This increases the chances of maximally complete destruction of cancer cells and a favorable prognosis.
Immunochemotherapy
The combination of chemotherapy and immunotherapy allows for simultaneous attacks on malignant cells and stimulation of the immune system to fight the tumour, increasing the overall effectiveness of treatment.
Targeted Therapy
One of the promising and hopeful directions of immunotherapy. Treatment with monoclonal antibodies targets the elimination of cells expressing specific antigens, in this case, antigens on the surface of B-lymphocytes. This targeted approach allows for the destruction of cancer cells while minimizing the impact on healthy tissues.
Radiation Therapy
Sometimes, in the treatment of precursor B-cell lymphoma, in addition to chemotherapy, it is advisable to conduct radiation sessions for localized destruction of cancer cells. At the Ihilov medical center, radiation therapy is performed using the most modern TrueBeam and Lunac linear accelerators. This equipment allows for precise targeting of the tumour, reducing the risk of damage to surrounding healthy tissues and side effects.
Stem Cell Transplantation
This is usually used after high doses of chemotherapy, which may affect the bone marrow. Transplantation allows for the restoration of healthy hematopoiesis. The Ihilov clinic performs two types of transplants:
- autologous, where the patient's own purified stem cells are used for transplantation,
- allogeneic, where the biological material for transplantation is taken from a donor.
- Stem cell treatment
- Radiation therapy
- Chemotherapy
- Targeted chemotherapy
Diagnostic Methods for the Disease
At the Ihilov clinic, the most current protocols, laboratory equipment, and instrumental tools are used to accurately and promptly diagnose precursor B-cell lymphoma. To clarify and confirm the diagnosis, three working days are usually required.
First Day
The doctor assesses symptoms, the presence of enlarged lymph nodes, liver, or spleen, as well as other signs that may indicate lymphoma. They review the medical history and collect the anamnesis.
Second Day
- Laboratory blood tests
- Immunophenotyping.
- Histological examination of lymph node biopsy or other affected tissues
- Molecular genetic tests
- Medical imaging studies: CT, MRI, PET
- Bone marrow biopsy
Third Day
At the Ihilov clinic, the results of diagnostic tests and analyses are interpreted by a team of clinicians, including oncologists, hematologists, histopathologists, radiologists, and specialists in radiation oncology, clinical geneticists, stem cell specialists, and transplantologists. A multidisciplinary approach, combining various specialized fields of medicine, ensures that no detail is overlooked and the most effective treatment strategy is developed.
- Biopsy
- Bone marrow biopsy
- Computed tomography
- Magnetic Resonance Imaging (MRI)
- Diagnosis — PET CT
How Much Does Treatment Cost
Patients from many countries choose the Israeli Ihilov clinic for treatment, thanks to the medical center's reputation and high quality of services. Despite the fact that the clinic practices the most current and effective methods of diagnosis and therapy, the cost of treatment programs here is more attractive than in hospitals in the USA and Europe. The cost of the treatment plan is formed individually, taking into account the stage of the disease, the number and complexity of treatment procedures.
A knowledgeable medical consultant will inform you about the cost and what a standard treatment program includes, what services are available to foreign patients, and where to find doctor ratings and reviews. You can obtain comprehensive information at any time by phone, through the feedback form, or chat-bot.
Advantages of Treatment in Israel
- Leading medical specialists
- Multidisciplinary approach and the latest technologies and treatment methods
- Personalized programs for each patient
- Practical experience in successful treatment and stem cell transplantation
- Quality organization of treatment and comfort of stay
Israel is one of the leading global destinations for the treatment of complex oncological diseases, including precursor B-cell lymphoma. The Ihilov clinic focuses on personalized medicine, which involves tailoring individual therapy for each patient. Schedule a video consultation (Zoom, Skype) with a doctor specializing in this field and learn firsthand about the most effective treatment methods and options for further actions in your specific case.