The Ichilov clinic employs a team of highly qualified specialists, many of whom have trained and interned at the best medical centers in the world. Significant experience in precise diagnostics and advanced approaches ensure successful treatment of precursor B-cell lymphoma in Israel. Patients receive an integrated assessment and treatment plan from a team of specialists, including hematologists, oncologists, histopathologists, radiologists, transplantologists, and doctors from other related fields. This provides a comprehensive approach to treatment and disease management.
Ichilov is equipped with advanced diagnostic and therapeutic equipment, allowing for the practice of the latest techniques. The doctors have access to targeted drugs, innovative chemotherapy, immunotherapy, as well as advanced radiation therapy methods using the latest generation linear accelerators.
Stays at Ichilov are organized to address all aspects of treatment, communication, transportation, and accommodation for patients and their families, allowing them to fully focus on recovery.
About the Disease
Precursor B-cell lymphoma (precursor B cell lymphoblastic lymphoma) is one of the subtypes of B-cell acute lymphoblastic leukemia (B cell ALL/LBL). It is a rare, aggressive type of non-Hodgkin lymphoma. The disease arises from cells that are precursors to normal B-cells, which are in the early stages of development, with blasts infiltrating extramedullary tissues.
According to the WHO's recommended updates to the classification of malignant lymphomas, pathologies are diagnosed based on the immunophenotypic characteristics of the cells. Lymphoblastic neoplasms are divided into:
B-cell lymphoblastic leukemia/lymphomas (B-cell ALL/LBL)
T-cell lymphoblastic leukemia/lymphomas (T-cell ALL/LBL)
In the modern classification, precursor B-cell lymphoma is classified as a subtype of B cell ALL/LBL. A characteristic feature of the pathology is overlapping clinical manifestations typical of both leukemia and lymphoma.
The exact causes of the disease are not fully understood. It is known that the oncological process begins with one or a series of genetic mutations in precursor B-cells, leading to their uncontrolled division and growth. Additionally, researchers suggest the influence of other risk factors, including radiation exposure, chemical carcinogens, and hereditary predisposition.
The most common signs of precursor B-cell lymphoma include:
- rapidly enlarging painless lymph nodes
- fever, night sweats, unexplained weight loss (B-symptoms)
- fatigue and weakness
- frequent infections due to suppressed immune response
- enlargement of the liver or spleen (hepatosplenomegaly)
- bone or joint pain.
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Treatment Methods for the Disease
Treatment of precursor B-cell lymphoma at the Ichilov clinic includes a combination of the most effective and promising methods, each selected based on the stage of the disease, the overall condition of the patient, and the goals of therapy.
Intensive Chemotherapy
The primary treatment method is based on the use of cytotoxic drugs to destroy malignant cells. Chemotherapy typically consists of several cycles and may combine a set of drugs to which rapidly dividing lymphoma cells are most sensitive. This increases the chances of maximizing the complete destruction of cancer cells and a favorable prognosis.
Immunochemotherapy
The combination of chemotherapy and immunotherapy allows for simultaneous attacks on malignant cells while stimulating the immune system to fight the tumor, increasing the overall effectiveness of treatment.
Targeted Therapy
One of the promising and innovative directions of immunotherapy. Treatment with monoclonal antibodies targets the elimination of cells expressing specific antigens, in this case, antigens on the surface of B-lymphocytes. This targeted approach allows for the destruction of cancer cells while minimizing the impact on healthy tissues.
Radiation Therapy
Sometimes, in the treatment of precursor B-cell lymphoma, in addition to chemotherapy, it is advisable to conduct radiation sessions for localized destruction of cancer cells. At the Ichilov medical center, radiation therapy is performed using the most modern TrueBeam and Lunac linear accelerators. This equipment allows for precise targeting of the tumor, reducing the risk of damage to surrounding healthy tissues and side effects.
Stem Cell Transplantation
This is usually used after high doses of chemotherapy, which may affect the bone marrow. Transplantation allows for the restoration of healthy hematopoiesis. The Ichilov clinic performs two types of transplants:
- autologous, where the patient's own purified stem cells are used for transplantation,
- allogeneic, where the biological material for transplantation is taken from a donor.
- Stem cell treatment
- Radiation therapy
- Chemotherapy
- Targeted chemotherapy
Diagnostic Methods for the Disease
At the Ichilov clinic, the most current protocols, laboratory equipment, and instrumental tools are used to accurately and promptly diagnose precursor B-cell lymphoma. To clarify and confirm the diagnosis, three working days are usually required.
First Day
The doctor evaluates symptoms, the presence of enlarged lymph nodes, liver, or spleen, as well as other signs that may indicate lymphoma. They review the medical history and gather the patient's history.
Second Day
- Laboratory blood tests
- Immunophenotyping.
- Histological examination of lymph node biopsy or other affected tissues
- Molecular genetic tests
- Imaging studies: CT, MRI, PET
- Bone marrow biopsy
Third Day
At the Ichilov clinic, the results of diagnostic tests and analyses are interpreted by a team of clinicians, including oncologists, hematologists, histopathologists, radiologists, and specialists in radiation oncology, clinical geneticists, stem cell specialists, and transplantologists. A multidisciplinary approach that combines various specialized fields of medicine allows for no detail to be overlooked and the development of the most effective treatment strategy.
- Biopsy
- Bone marrow biopsy
- Computed tomography
- Magnetic Resonance Imaging (MRI)
- Diagnosis — PET CT
How Much Does Treatment Cost
Patients from many countries choose the Israeli Ichilov clinic for treatment due to the medical center's reputation and high quality of services. Although the clinic practices the most current and effective methods of diagnosis and therapy, the cost of treatment programs here is more attractive than in hospitals in the USA and Europe. The cost of a treatment plan is formed individually, taking into account the stage of the disease, the number and complexity of treatment procedures.
A knowledgeable medical consultant will inform you about the cost and what is included in the standard treatment program, what services are available to foreign patients, and where to find doctor ratings and reviews. You can obtain comprehensive information at any time by phone, through the feedback form, or chat-bot.
Advantages of Treatment in Israel
- Leading medical specialists
- Multidisciplinary approach and the latest technologies and treatment methods
- Personalized programs for each patient
- Practical experience in successful treatment and stem cell transplantation
- Quality organization of treatment and comfort of stay
Israel is one of the leading global destinations for the treatment of complex oncological diseases, including precursor B-cell lymphoma. The Ichilov clinic focuses on personalized medicine, which involves tailoring individual therapy for each patient. Schedule a video consultation (Zoom, Skype) with a doctor specializing in this area and learn firsthand about the most effective treatment methods and options for further actions in your specific case.