Regular investments in modern technologies and equipment, advanced developments, and experienced personnel ensure the effectiveness of treatment for undifferentiated pleomorphic sarcoma in Israel. This country is one of the leaders in oncology and the treatment of soft tissue sarcomas. Doctors and oncologists at Ichilov have international experience and regularly participate in scientific research, allowing them to utilize the most current treatment methods.
Ichilov clinic adheres to a policy of personalization. Each therapeutic strategy is adapted to the unique needs of the patient and the characteristics of the disease's progression. Treatment is based on multidisciplinary teams consisting of oncologists, surgeons, radiologists, pathologists, and other specialists, enhancing the quality of diagnostics and therapy.
Patients at Ichilov clinic have access to innovative treatment methods. Some experimental drugs in clinical trials are available exclusively in Israel. Significant attention is given to patient support, including assistance with translation, organizational, logistical, and everyday issues, which is especially important for foreign patients.
About the Disease
Undifferentiated pleomorphic sarcoma is one of the types of soft tissue sarcomas. It is a malignant tumor that develops in the connective and supportive tissues of the body – muscles, adipose and fibrous tissue, blood vessels, and nerves.
The causes of this disease are not fully understood. It is believed that the pathology arises from the accumulation of genetic mutations. Factors that may increase the risk of developing undifferentiated pleomorphic sarcomas include:
- genetic disorders, hereditary syndromes;
- previous radiation exposure;
- chemical carcinogens;
- chronic inflammatory diseases;
- traumatic impact on tissues.
Symptoms can be nonspecific, depending on the tumor's location and growth rate. The most characteristic sign is the formation of a lump or tumor, pain or discomfort if the tumor presses on nerves or nearby organs.
If the formation is located near joints or in muscles, there may be a decrease in mobility. Additionally, weight loss, fatigue, swelling, or a feeling of tension in the area of the tumor may occur.
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Treatment Methods for the Disease
Treatment for patients with undifferentiated pleomorphic sarcomas at Ichilov clinic is developed considering the size and location of the tumor, the stage of the disease, the overall condition, and the presence of metastases.
Surgical Treatment
The main tactic for combating undifferentiated pleomorphic sarcoma is the surgical removal of the tumor. During the operation, the doctor aims to remove all malignant tissue as completely as possible. Resection is performed with clear margins, meaning with a margin of healthy tissue. Removing a small amount of uninfected tissue around the tumor helps prevent the spread of cancer cells and minimizes the risk of recurrence. Ichilov clinic employs experienced oncological surgeons who practice the latest surgical approaches and maximize organ-preserving surgeries.
Radiation Therapy
Radiation may be used before surgery – neoadjuvant therapy – to reduce the size of the tumor. In cases where adjuvant therapy is prescribed, radiation is used to destroy remaining cancer cells.
Ichilov Medical Center has the most modern linear accelerators, TrueBeam and Lunac, for radiation therapy. These devices are characterized by high precision and an intelligent system for distributing radiation exposure. Modern radiation therapy minimizes damage to healthy tissues near the tumor and reduces side effects.
Chemotherapy
Chemotherapy as a primary treatment method for undifferentiated pleomorphic sarcoma is rarely used. This is due to the limited sensitivity of this type of cancer to chemotherapeutic agents. However, in some cases, such as with disseminated tumors, chemotherapy is included in the treatment regimen.
Targeted Therapy and Immunotherapy
The treatment options for undifferentiated pleomorphic sarcoma have expanded with the emergence of new drugs targeting specific molecular changes in cancer cells. Alongside traditional approaches, Ichilov clinic employs targeted therapy and specific immunostimulation.
Cryotherapy
The procedure involves freezing tumors using liquid nitrogen, which is delivered to the tumor via a special probe. This method is considered an alternative in cases where surgical intervention is not possible. Its advantages include low invasiveness, the possibility of being performed under local anesthesia, no severe postoperative period, and quick recovery.
- Radiation therapy
- Chemotherapy
Diagnostic Methods for the Disease
The diagnosis of undifferentiated pleomorphic sarcoma (UPS) at Ichilov clinic involves several stages and requires a comprehensive approach. Typically, analyzing the results of studies and establishing a diagnosis takes three days.
First Day
First, the doctor conducts a general examination and collects a medical history to assess symptoms and understand the patient's medical background.
Second Day
Laboratory tests and imaging techniques are used to identify the neoplasm, determine its location, and assess the tumor's spread.
- Laboratory tests including complete blood count and biochemical analysis to assess the patient's overall health and organ function.
- MRI for detailed imaging of the body's soft tissues.
- CT to assess the tumor's size and its interaction with nearby structures, as well as to search for possible metastases.
- PET is useful in staging the disease to identify metastases.
- X-rays to assess the involvement of bone structures in the pathological process.
- Biopsy – a key method for confirming the diagnosis and determining the type of tumor. This procedure involves obtaining a tissue sample from the tumor for microscopic examination.
- Histological examination of the sample obtained during the biopsy to determine the type and aggressiveness of the tumor cells.
- Molecular genetic testing may be used to identify specific genetic anomalies that may affect treatment and disease prognosis.
Third Day
Each case of UPS is unique and is adapted to the specific patient. A multidisciplinary team, including a surgeon, oncologist, radiologist, pathologist, and other specialists, develops the most effective treatment plan. The team of doctors evaluates all possible options, risks, and side effects. In each specific case, a set of the most reasonable and promising treatment measures is determined.
- Biopsy
- Computed Tomography
- Magnetic Resonance Imaging (MRI)
- Diagnostics – PET CT
- X-ray
- Blood Biochemistry
How Much Does Treatment Cost
The cost of treatment at Ichilov clinic depends on the specifics of each case. The price is influenced by the stage of the disease and the patient's current condition at the time of admission. This affects the range of diagnostic procedures and the complexity of treatment.
You can call a qualified medical coordinator to find out the cost of treatment at Ichilov. The specialist will introduce you to doctor ratings and patient reviews, explain the details of organizing your trip. You can ask questions in the online chat or through a special form on the website.
Advantages of Treatment at Ichilov Clinic
- High level of medical care
- Experienced medical staff
- Individual approach and multidisciplinary teams of specialists
- Access to the latest treatment procedures
- Comfort, support, language accessibility
Treatment of the disease should be based on current scientific data and meet the individual needs of the patient. Schedule a video call via Zoom or Skype and receive a consultation from a leading specialist in sarcoma treatment. With complete information, you will be able to thoughtfully discuss and consider all available options to determine the best one.