Treatment of Acute Myeloid Leukemia in Israel — Innovative Methods and Excellent Results

Professor Ella Naparstek

leading hematologist and hemato-oncologist

The high qualifications and expertise of Israeli oncologists specializing in hematology, their mastery of treatment methods for malignant blood pathologies, and their ability to provide a favorable prognosis even in the most severe cases are recognized worldwide. Treatment of acute myeloid leukemia in Israel is conducted according to a comprehensive program tailored for each patient, taking into account the specifics of their oncogenesis. The use of innovative techniques such as targeted therapy and immunotherapy, along with chemotherapy using the latest drugs, allows for achieving durable remission in more than 95% of cases. For patients choosing a clinic for treatment, positive feedback from patients serves as the best evidence of effective treatment of blood oncopathologies in Israel.

95%

of cases with durable remission

100%

accuracy of molecular genetic tests

100%

diagnostic accuracy

Get prices at the clinic

Table of Contents

Treatment Methods

Diagnosis

Prices

Reviews

Successful treatment of such an aggressive oncological disease as acute myeloid leukemia requires accurate diagnosis at an early stage. Diagnostic centers of leading clinics in Israel are equipped with high-tech equipment that allows for prompt acquisition of highly accurate information. The treatment plan is developed by a medical council consisting of a hematologist and several specialized experts. Treatment of hemato-oncological pathologies is conducted by qualified doctors with extensive experience, who regularly undergo internships at the largest clinics in the world. For many medical tourists from abroad, the affordable cost of therapy, significantly lower than in Western Europe and the USA, is attractive.

Treatment in Israel Restores Hope

Treatment Methods for the Disease

The comprehensive therapy program includes the most effective methods for the patient, selected based on the results of diagnostic examinations and molecular genetic testing. Treatment of acute myeloid leukemia is carried out using the most progressive techniques and the latest generation of chemotherapy drugs.

Chemotherapy

It is the primary method of treating this pathology, as in blood cancers, a pathological focus typically does not form, and malignant cells are spread throughout the body via the bloodstream. To slow the progression of the disease, eliminate clinical signs, and destroy cancer cells, systemic intervention is necessary through the administration of chemotherapy drugs into the bloodstream. Typically, the chemotherapy course is divided into two phases:

• Induction — aimed at maximizing the destruction of malignant blood cells and halting disease progression. The types of cytostatic chemotherapy drugs, their administration regimen, and dosage are tailored for each patient, considering information obtained from examinations and other factors. Circulating in the blood, chemotherapy drugs penetrate cancer cells, causing irreversible DNA damage and thereby preventing growth and division. The formation of remission and its duration largely depend on the type of malignant cells and their sensitivity to the prescribed chemotherapy drugs.
• Consolidation — conducted to eliminate any remaining malignant cells in the patient's body and restore normal hematopoietic activity. Without the consolidation phase, the likelihood of leukemia relapse increases several times. Alongside the use of cytostatic drugs, supportive therapy is prescribed to alleviate painful symptoms, strengthen immunity, and normalize overall condition.

During chemotherapy, the patient must be under constant medical supervision. Israeli clinics use the latest generation of chemotherapy drugs, which are characterized by lower toxicity and cause minimal side effects in patients.

Immunotherapy

Treatment of acute myeloid leukemia with immunotherapeutic agents based on monoclonal antibodies specific to this type of malignant cells. Monoclonal antibodies overcome the masking of cancer cells, recognize them, and promote their destruction by the patient's immune cells. An undeniable advantage of these drugs is their targeted action on pathological cells without harming healthy ones, resulting in the absence of side effects.

Specific anti-tumor vaccines are also used to activate the immune system, which include non-viable malignant blood cells from the patient, modified using genetic engineering technologies.

Bone Marrow Transplantation

The most effective method for treating this hemato-oncological disease. There are several reasons why a patient may require a bone marrow transplant. The main reason is that to achieve a positive effect, large doses of cytostatics are administered, which destroy not only cancerous but also healthy blood cells. As a result, there is significant suppression of hematopoietic function and weakening of the immune system, for which the transplantation of viable stem cells is necessary. For transplantation, the patient's own bone marrow, obtained before the start of chemotherapy (autologous transplantation), or material from a maximally compatible donor, usually a close relative of the patient (allogeneic transplantation), is used. Before the transplantation procedure, the patient undergoes a course of high-dose chemotherapy. Since restoring the body's protective functions takes time, after transplantation, the patient is placed in a sterile box to minimize the risk of infection.

Radiotherapy

In some cases, malignant cells accumulate in the spleen or lymph nodes. To destroy pathological foci, the patient is indicated for radiation therapy. In Israeli medical centers, radiation therapy sessions are conducted on the latest equipment, which ensures the most precise irradiation of the oncogenesis. Patient safety is ensured by minimal impact on healthy tissues, significantly reducing the number and severity of complications.

How the Disease is Diagnosed

Thanks to diagnostic procedures performed on high-tech equipment, the reliability of the obtained results is nearly 100%. The comprehensive examination takes, on average, no more than three days.

First Day

During the initial consultation, the treating hematologist reviews the patient's medical history, conducts a physical examination, and orders necessary tests.

Second Day

The patient undergoes the ordered examinations, which include:

• general and biochemical blood tests;
• identification of specific tumor markers in the blood;
• bone marrow biopsy followed by histological analysis of the obtained samples;
• collection of cerebrospinal fluid (CSF) via lumbar puncture and subsequent laboratory examination of the obtained material;
• visual imaging methods (CT, MRI, PET-CT) — conducted to determine the localization of the oncogenesis, assess the condition of surrounding tissues, and identify distant metastases.

Third Day

A medical council, which includes the treating hematologist and several specialized experts, reviews the obtained examination results, makes a final diagnosis, and develops a treatment plan.

How Much Does Treatment Cost

Advantages of Treatment in Israel

• High qualifications and expertise of doctors, many of whom are world-renowned.
• Equipping clinics with modern therapeutic and diagnostic equipment.
• Application of progressive treatment methods.
• Comfortable conditions for undergoing treatment.
• Affordable prices.

Blood cancers are not a death sentence, and with modern methods, complete recovery can be successfully achieved. The main thing is not to waste precious time and to start treatment at the chosen clinic as soon as possible.