The Ichilov Clinic is equipped with modern diagnostic and therapeutic equipment of the latest generation. Here, high-precision diagnostics are performed, and the most advanced and effective methods for treating Lennert's lymphoma in Israel are applied. The medical center employs oncologists and hematologists who are recognized globally and have successful experience in treating complex and rare forms of oncological hematological pathologies.
Treatment is conducted by multidisciplinary teams that comprehensively and effectively manage the therapy process. The clinic combines proven methods, innovative approaches, and the latest pharmacological developments.
Ichilov has been receiving patients from other countries for many years, providing assistance with organization, logistics, translation, personal accompaniment, and accommodation for patients' families.
About the Disease
Lennert's lymphoma (lymphoepithelioid, lymphoepithelioid-cell, lymphoma-like, Lennert lymphoma) is a rare pathology with a unique histological structure. According to the WHO classification, it belongs to the general category of Hodgkin's lymphomas – unspecified peripheral T-cell lymphomas. However, the pathology actually arises from B-lymphocytes – white blood cells involved in the immune response. The features of morphology and immune response are due to a two-component cellular composition of epithelioid histiocytes and small lymphoid cells.
The exact causes of Lennert's lymphoma have not yet been established. Researchers suggest the possibility of influence from genetic and external factors, viral infections such as Epstein-Barr virus.
Lennert's lymphoma may progress more aggressively than other subtypes of Hodgkin's lymphoma. Symptoms of the pathology may include swollen lymph nodes, fever, night sweats, unintentional weight loss, skin itching, and fatigue. Some patients experience tenderness in the enlarged lymph nodes.
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Treatment Methods for the Disease
Treatment of Lennert's lymphoma is a complex process that requires an individualized approach, depending on the stage of the disease, the overall condition of the patient, and the response to therapy. Each case of Lennert's lymphoma is unique, and the treatment approach is adapted to the specific needs of the patient.
Chemotherapy
Chemotherapy is the cornerstone of treatment for Lennert's lymphoma. It can be used as monotherapy or in combination regimens. The most common chemotherapy regimens are ABVD and BEACOPP. The combination of drugs, dosage, and scheme depend on many factors, including the stage of the disease, response, and the patient's health status.
Immunotherapy
Immunotherapy uses biological agents to stimulate the body's own defense mechanisms to fight cancer. In the treatment of Lennert's lymphoma, therapy with monoclonal antibodies shows effectiveness. Laboratory-created antibodies against CD20 specifically target certain parameters of protein molecules and the associated cancer antigen, without affecting healthy cells.
Radiotherapy
Radiotherapy may be used in cases of localized Lennert's lymphoma to destroy cancer cells in specific areas. This approach is most appropriate when there are specific sites where the disease manifests most significantly. Radiotherapy can be used as a standalone treatment method or in combination with chemotherapy to increase effectiveness.
At Ichilov, modern high-precision linear accelerators TrueBeam and Lunac are used. This state-of-the-art radiotherapy equipment allows for precise targeting of the tumor according to its shape and size. The IMRT mode changes the intensity of the beam during the current session, delivering high doses of radiation directly to the tumor areas while reducing the dose that reaches surrounding healthy tissues. CT scanning and MRI functions allow doctors to monitor the position and size of the tumor in real-time, adapting the radiotherapy plan.
Visceral Therapy
Lennert's lymphoma can spread beyond the lymphatic system, affecting internal organs and causing various symptoms and complications. In cases of internal organ involvement, visceral therapy may be required. This is a set of measures aimed at treating lesions of internal organs caused by the tumor. The goals of therapy are:
- to reduce the tumor mass in the affected internal organ,
- to prevent the spread of the disease to other parts of the body,
- to improve overall condition and quality of life.
Methods of visceral therapy include a combination of anticancer drugs, biological agents, and monoclonal antibodies, as well as targeted radiotherapy.
The importance of visceral therapy lies in its comprehensive impact not only on the primary focus of the disease in the lymphatic system but also on the affected internal organs. This approach increases the chances of a successful prognosis, helps manage symptoms, and prevents complications related to the dysfunction of the affected organs.
Autologous Stem Cell Transplantation
For patients with relapsed or refractory Lennert's lymphoma, autologous stem cell transplantation may be considered. This procedure involves returning the patient's own previously collected, processed, and preserved stem cells. Stem cell transplantation is most appropriate after high-intensity chemotherapy, in cases of risks or recurrence.
- Bone marrow transplantation in Israel
- Radiotherapy
- Chemotherapy
Diagnostic Methods for the Disease
This rare disease is characterized by granulomatous proliferation, similar to manifestations of other pathologies. At Ichilov, protocols have been developed to accurately identify Lennert's lymphoma, excluding morphologically similar Hodgkin's disease, angioimmunoblastic adenopathy, and sarcoid granuloma.
The variety of manifestations and cross-morphological characteristics require a comprehensive approach to diagnostics, which is conducted in stages and usually takes three days.
First Day
The doctor collects complaints, reviews the patient's medical history, and takes a history. A complete physical examination is conducted.
Second Day
- Blood tests
- Lymph node biopsy
- Immunophenotyping for accurate identification of the type of lymphoma
- Molecular genetic studies: polymerase chain reaction, sequencing
- Imaging tests: CT, PET, MRI
Third Day
At Ichilov, the diagnosis is confirmed by a multidisciplinary group analyzing symptoms and results from histology, immunophenotyping, molecular tests, and imaging. A collegial approach allows for a comprehensive assessment of manifestations, establishing the stage of the disease, and selecting the most effective treatment strategy.
- Biopsy
- Computed Tomography
- Magnetic Resonance Imaging (MRI)
- Diagnostics — PET CT
What is the Cost of Treatment
Each treatment program at Ichilov is developed individually. The cost of services is based on the volume and complexity of diagnostic procedures, treatment methods, and the need for specialized manipulations or expert consultations.
Call, write in the online chat on our website, or use the feedback form. A healthcare coordinator will provide detailed information about what affects the price and what is included in the treatment program. Get up-to-date information about the medical equipment available at the clinic, the specialization of departments, the qualifications and experience of doctors, their reputation, and patient reviews.
Advantages of treatment at Ichilov Clinic
- Modern medical technologies;
- Highly professional specialists working as a team;
- Personalized approach to each patient;
- Application of integrative medical approaches, the latest treatment methods and drugs validated by clinical trials;
- Experience in organizing treatment for international patients.
Israel is known for its achievements in treating oncological hematological pathologies of the lymphatic system. Today, from anywhere in the world, you can consult with a leading expert in this field using video communication via Zoom or Skype. Order a remote consultation, and the doctor will evaluate the condition based on the available conclusions and test results and suggest options for further action.