Israel is known for its advanced achievements in oncology. The Ichilov Clinic utilizes the latest technologies and treatment methods for plasmablastic B-cell lymphoma in Israel, providing patients access to innovative therapy options. The medical center employs many highly qualified doctors and researchers, recognized experts in the study and fight against oncological pathologies.
At Ichilov, an individual approach is practiced, carefully tailoring treatment programs to the specific needs of each patient. As part of a multidisciplinary strategy, specialists from various fields: oncologists, hematologists, histopathologists, surgeons, radiologists, and others, select the most effective treatment options. In addition to treating the primary disease, Ichilov provides psychological support, rehabilitation, and other types of ancillary care. The medical center actively conducts research and clinical trials of new approaches and drugs unavailable in other parts of the world.
At Ichilov, they value every hour, and thanks to effective and consistent organization of work, they minimize the time required for confirming diagnoses and starting treatment. Here, comprehensive services for foreign patients are offered, including assistance with transfers, accommodation, and translation services.
About the Disease
Plasmablastic lymphoma is a rare and aggressive subtype of non-Hodgkin lymphomas. The disease is characterized by pronounced proliferation of cancer cells resembling plasmablasts. These cells are a type of B-cell that is in the process of transforming into plasma cells that produce antibodies.
Plasmablastic lymphoma most commonly occurs in individuals with immunodeficiencies, such as HIV infections and other immunodeficiency states, including organ transplants and severe immunodeficiency diseases. The true causes of this type of lymphoma are not fully understood. It is believed that genetic and some external factors may provoke the disease.
The most common and characteristic signs include:
- enlargement of lymph nodes, which is usually not accompanied by pain;
- systemic manifestations such as fever, weight loss, and night sweats;
- fatigue;
- lesions or neoplasms in the oral cavity;
- lesions of internal organs and bones.
Manifestations may vary depending on the extent and localization of the disease.
Treatment Methods for the Disease
Treatment of plasmablastic B-cell lymphoma at the Ichilov Clinic is based on current protocols, according to a personalized plan tailored to the specific patient.
High-Dose Chemotherapy
This is the primary treatment strategy for plasmablastic B-cell lymphomas. Therapy is most often based on the administration of combinations of several antitumor drugs. The dosage of the drugs and the regimen are selected individually depending on the stage of the disease and clinical manifestations. Treatment is conducted in courses with mandatory breaks for recovery. The goal of therapy is to achieve the maximum possible destruction of cancer cells, remission, and optimization of prognosis.
Radiation Therapy
Radiation therapy in the treatment of plasmablastic B-cell lymphomas can be applied:
- to control localized forms of plasmablastic lymphoma;
- in situations where chemotherapy alone is insufficient to achieve the desired effect.
The Ichilov Clinic is equipped with the latest models of TrueBeam and Lunac linear accelerators. This equipment provides high-precision radiation exposure to the tumour and minimizes the risks of damaging surrounding healthy tissues, thereby increasing the effectiveness and safety of treatment.
Targeted Therapy and Immunotherapy
Promising innovative approaches to the treatment of plasmablastic lymphoma.
The basis of immunological treatment is methods that stimulate the body's own forces to recognize and destroy malignant cells.
Targeted therapy is one of the directions of immunotherapy. This method is based on drugs that target specific molecular targets. As a result, cancer cells are selectively destroyed or their ability to divide and develop is blocked.
Autologous Stem Cell Transplantation
In some cases, transplantation of the patient's own stem cells may be performed. They are collected and processed through special purification procedures. After high-dose chemotherapy sessions to destroy remaining cancer cells, the preserved biological material is returned to the patient's body to restore bone marrow function.
- Stem cell treatment
- Radiation therapy
- Chemotherapy
Diagnosis Methods for the Disease
Due to the rarity and aggressiveness of the disease, as well as the variety of symptoms, early and accurate diagnosis is a key point for starting effective treatment. The Ichilov Medical Center is equipped with the latest laboratory equipment and diagnostic imaging technology. The diagnostic program includes immunophenotyping, which allows for the precise identification of the type of lymphocytes constituting the lymphoma, and histopathological testing to assess the morphology of the transformed cells.
First Day
The doctor discusses symptoms with the patient, compiles a medical history, and assesses risk factors, including HIV infection or conditions associated with immunosuppression. During a thorough physical examination, the patient is checked for enlarged lymph nodes, lesions in the oral cavity, and other physical signs that may indicate lymphoma.
Second Day
- Laboratory studies
- Biopsy of the affected node or tissue with subsequent immunohistochemical tests
- Immunophenotyping
- Molecular and genetic studies to determine genetic mutations and chromosomal abnormalities
- Computer imaging: CT, MRI, PET.
Third Day
In confirming the diagnosis and developing a treatment plan, a multidisciplinary team of specialists at the Ichilov Clinic is involved, which may include: hematologist-oncologists, infectious disease specialists, radiologists, histologists, molecular genetic researchers, surgeons, and doctors from other fields. The team comprehensively evaluates the diagnostic results and selects an individual treatment plan based on the obtained data, overall health status, and stage of the disease.
- Computed Tomography
- Magnetic Resonance Imaging (MRI)
- Diagnosis — PET CT
- Biopsy and histological studies
How Much Does Treatment Cost
A personalized treatment plan is developed for each patient at the Ichilov Clinic. The final cost depends on the stage of the disease and the condition at the time of arrival at the hospital. Depending on the number and complexity of diagnostic and therapeutic procedures, the price of the treatment program may vary for different patients.
Call a medical consultant to find out the average cost of treatment programs at Ichilov. Through the chatbot or a special form, you can ask any questions and clarify organizational and financial aspects of the trip. The consultant will guide you on where to read in detail about the clinic's capabilities, see what the departments look like, and check ratings and reviews.
Advantages of Treating Plasmablastic B-cell Lymphoma in Israel
- Advanced medicine and highly qualified specialists
- Individual approach to each case of the disease
- Multidisciplinary teams of specialists
- Wide range of services provided
- Excellent organization of medical care, comfort, and support
Modern medical technologies allow for the maximum reduction of waiting time from the treatment request to its approval and the start of diagnostic and therapeutic procedures. Today, you can schedule a consultation with a leading specialist in oncological hematology and receive an expert assessment of your situation and recommendations for further actions via video call through Zoom or Skype.