New Medications for Diabetes Treatment in Israel

Professor Ardon Rubinstein

head of the metabolic disorders treatment center

The Top Ichilov Medical Center is one of the leading national medical centers in Israel. Our specialists focus on a comprehensive, multidisciplinary, and individualized approach to the patient, achieving unique results.

The center provides treatment for diabetes and its complications using the most modern techniques. What news do scientific studies bring us in the field of diabetes? An important direction in research is the synthesis of new medications that facilitate the delivery of insulin to tissues without injections. Over the past twenty years, the biosynthesis of protein compounds, based on recombinant ribonucleic acid technology, has reached a level that allows for the commercial production of compounds such as hormones, growth factors,
monoclonal antibodies, and cytokines.

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30%

of diagnoses made in CIS countries are found to be erroneous at the Top Ichilov clinic

78%

successful cases of disease treatment with medications

24

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The advantages of parenteral (administered bypassing the gastrointestinal tract) prolonged-action medications include:

• increased amount of protein reaching the therapeutic action zone of the medication
• improved transport of the drug to its action zone
• the possibility of combining the main medication with other ingredients (such as absorption enhancers or protease inhibitors)
• improved stability of the medication in the body
  increased active time of the drug in tissues by suppressing mechanisms of its degradation
• reduced transport of the drug outside the therapeutic action zone
• reduced irritation of tissues by the medication
• decreased toxicity of the drug, even after administering high doses
• impact on the immunogenicity of protein structures

The effect of insulin inhalation on lung function is still being studied, as well as the effect of lung diseases on its absorption and pharmacokinetics; whether the risk of lung cancer increases in former smokers.

Studies of diabetic patients have shown that prolonged use of insulin causes morphological changes in the lung structure such as: thickening of the alveolar-capillary membrane, hyalinosis of blood vessels, formation of granulomas, nodular fibrosis, as well as obliteration of the interalveolar space, which is seen in emphysema. These changes depend not only on the severity of the disease but also on other factors, such as smoking.

The task of researchers is to find the optimal combination of parenteral therapy with maximum safety in use. Doctors and the research staff of the Top Ichilov Medical Center are actively working to improve the quality of life for diabetic patients.

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Diabetes Treatment in Israel: Patient Review