Liver cancer treatment at Ichilov (Sourasky) clinic, Tel Aviv

Liver cancer is one of the most complex oncological diseases: the tumor often develops against the background of cirrhosis or chronic hepatitis, so treatment requires the simultaneous efforts of oncologists, hepatologists, transplant surgeons, and interventional radiologists. At Ichilov (Sourasky Medical Center) in Tel Aviv, patients undergo this entire journey as part of one team: from initial diagnosis to liver transplantation or last-line systemic therapy.

Here, all major forms are treated — hepatocellular carcinoma (HCC), cholangiocarcinoma (cancer of the intrahepatic and extrahepatic bile ducts), as well as metastatic liver involvement in colorectal cancer, breast cancer, neuroendocrine tumors, and melanoma. Diagnosis includes MRI of the liver with hepatospecific contrast (Primovist), CT with triple-phase contrast, PET-CT, elastography, and ultrasound-guided biopsy; markers AFP, PIVKA-II, and molecular profiling of the tumor guide therapy selection.

The strategy at Ichilov is based on the BCLC stage. In early stages, liver resection (including laparoscopic and robot-assisted), radiofrequency and microwave ablation (RFA/MWA), and, when appropriate criteria are met, liver transplantation are performed. In intermediate stages, transarterial chemoembolization (TACE) and radioembolization (SIRT/Y-90) are used. In advanced stages, modern systemic therapy is introduced: combinations of immunotherapy (atezolizumab + bevacizumab, durvalumab + tremelimumab) and first- and second-line targeted therapies — sorafenib, lenvatinib, regorafenib, cabozantinib.

This section contains materials on how liver cancer diagnosis is conducted at the Sourasky clinic, what treatment methods are applied at different stages, how approaches differ for HCC and metastases, the cost of treatment, and how to arrange travel from abroad. Here, you will also find specialized hepatologists and surgeons who manage patients with liver tumors.